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KMID : 0880220170550010001
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Journal of Microbiology
2017 Volume.55 No. 1 p.1 ~ p.12
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The therapeutic applications of antimicrobial peptides (AMPs): a patent review
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Kang Hee-Kyoung
Kim Cheol-Min
Seo Chang-Ho
Park Yoon-Kyung
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Abstract
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Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.
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KEYWORD
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antimicrobial peptide, therapies, drug candidate, pathogenic bacteria
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